Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length459 amino acids

Chemical FormulaC2295H3689N601O633S19

DescriptionStandard

        MLPLCCILALLASFCHDTSGTTAGVKVKLTQRGLEYGQKIGIPILLKKLKAIDLPEMNDSVGVFLIGRVAYSLTRMKVLNVRLPQSAVGLVPGIGVSLTISDGYIDTGGNWRVKFLGFISDSGTFDLSVCGLTITTTITIKSDGTGRPMVRSANCEASLSHARIRLRGGASWLYNMFNGYINKEVRKELQRKICPLVSENIQKINSYMKTLNGELKDHYRTFNYTDKTGEFYNIGVHKKPAFAPTPFSLPPNERNMLYMGISAFTANSAGFVYKNAGALTLRITDDMIPRASPYRLNTKTFEALIPQIAKQYPNMMIKLLVKAATAPTVTFAPNNVTLQANTTVTVYAIQPNTTLTTLFILNVDASLSAHVYVIGKNLAGKLSLNKFNINLGTSYIGPFKVKPLAYFLQIMLKIVIPHVNVILQRGFPLPNIANISLVKPGLVIMKDYVLIGTDVQFKP
    

Molecular Weight50437.72 Da

Isoelectric Point (pI)9.78

Net Charge (pH 7.0)24.96

Net Charge (pH 7.4) 24.25

Charge Density (pH 7.0) 0.0544

GRAVY Index0.16

Hydrophobic Moment 0.75

Boman Index0.14

Instability Index26.42

Aliphatic Index 104.07

Aromaticity 0.0871

Extinction Coeff. Reduced 37820.00

Extinction Coeff. Oxidized 38195.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0412062 VERIFIED: NO

Provenance & Taxonomy

OrganismElectrophorus electricus [Animal]

FamilyBPI

Tax ID8005

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence