Peptide Database

Peptide NameSLAY-screened peptide P2357

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC109H164N30O35S2

DescriptionStandard

        SEIFNNYTREKHCCPNSLTVY
    

Molecular Weight2518.78 Da

Isoelectric Point (pI)6.47

Net Charge (pH 7.0)-0.47

Net Charge (pH 7.4) -0.76

Charge Density (pH 7.0) -0.0224

GRAVY Index-0.76

Hydrophobic Moment 0.43

Boman Index-0.13

Instability Index29.40

Aliphatic Index 50.95

Aromaticity 0.1429

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1078.38

LogP -12.19

H-bond Donors 39.0

H-bond Acceptors 38.0

Rotatable Bonds 79.0

Heavy Atoms 176.0

Ring Count 5.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0103379 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/