Peptide Database

Peptide NameBeta-defensin 109

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length87 amino acids

Chemical FormulaC445H746N128O109S10

DescriptionStandard

        MRLHLLLLILLLFSILLSPVRGGLGPAEGHCLNLSGVCRRDVCKVVEDQIGACRRRMKCCRAWWILMPIPTPLIMSDYQEPLKRKLK
    

Molecular Weight9954.13 Da

Isoelectric Point (pI)9.69

Net Charge (pH 7.0)7.62

Net Charge (pH 7.4) 7.20

Charge Density (pH 7.0) 0.0876

GRAVY Index0.30

Hydrophobic Moment 0.66

Boman Index0.06

Instability Index67.88

Aliphatic Index 123.22

Aromaticity 0.0460

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3763.77

LogP -23.73

H-bond Donors 139.0

H-bond Acceptors 129.0

Rotatable Bonds 332.0

Heavy Atoms 692.0

Ring Count 14.0

Amide Bonds 89.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0288134 VERIFIED: NO

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyDefensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KL7/entry; https://bblserver.org.in/ampdb/