Peptide Database

Peptide NameC-MP1-1

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC77H133N19O17

DescriptionStandard

        IDWKKLLKAAKGIL
    

Molecular Weight1597.00 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.1969

GRAVY Index0.26

Hydrophobic Moment 0.68

Boman Index0.11

Instability Index-1.21

Aliphatic Index 153.57

Aromaticity 0.0714

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 598.79

LogP -0.68

H-bond Donors 21.0

H-bond Acceptors 20.0

Rotatable Bonds 57.0

Heavy Atoms 113.0

Ring Count 2.0

Amide Bonds 13.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0128564 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyPolybia-MP1

Tax ID32630

Structure & Mods

Configtriazole-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsThe Ⓚ (position: 8) is lysine with the methyltrityl side chain. The Ⓖ (position: 12) is propargylglycine. Ⓚ (8) and Ⓖ (12) are cross-linked by hydrocarbon stapling by 1,3-diploar azide-alkyne cyclization

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli ATCC 25922

Activity64 μM

MethodMIC

PaperBeijun Liu, Wei Zhang, Sanhu Gou, Haifeng Huang, Jia Yao, Zhibin Yang, Hui Liu, Chao Zhong, Beiyin Liu, Jingman Ni, Rui Wang. Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity. J Pept Sci. 2017 Nov;23(11):824-832. Epub 2017 Aug 23. PMID28833783 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28833783/

RECORD: Rec_0167538 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyPolybia-MP1

Tax ID32630

Structure & Mods

Configtriazole-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsThe Ⓚ (position: 8) is lysine with the methyltrityl side chain. The Ⓖ (position: 12) is propargylglycine. Ⓚ (8) and Ⓖ (12) are cross-linked by hydrocarbon stapling by 1,3-diploar azide-alkyne cyclization

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetBacillus subtilis ATCC 23857

Activity8 μM

MethodMIC

PaperBeijun Liu, Wei Zhang, Sanhu Gou, Haifeng Huang, Jia Yao, Zhibin Yang, Hui Liu, Chao Zhong, Beiyin Liu, Jingman Ni, Rui Wang. Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity. J Pept Sci. 2017 Nov;23(11):824-832. Epub 2017 Aug 23. PMID28833783 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28833783/

RECORD: Rec_0293794 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyPolybia-MP1

Tax ID32630

Structure & Mods

Configtriazole-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsThe Ⓚ (position: 8) is lysine with the methyltrityl side chain. The Ⓖ (position: 12) is propargylglycine. Ⓚ (8) and Ⓖ (12) are cross-linked by hydrocarbon stapling by 1,3-diploar azide-alkyne cyclization

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStaphylococcus aureus ATCC 25923

Activity64 μM

MethodMIC

PaperBeijun Liu, Wei Zhang, Sanhu Gou, Haifeng Huang, Jia Yao, Zhibin Yang, Hui Liu, Chao Zhong, Beiyin Liu, Jingman Ni, Rui Wang. Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity. J Pept Sci. 2017 Nov;23(11):824-832. Epub 2017 Aug 23. PMID28833783 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28833783/

RECORD: Rec_0387885 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyPolybia-MP1

Tax ID32630

Structure & Mods

Configtriazole-stapled side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsThe Ⓚ (position: 8) is lysine with the methyltrityl side chain. The Ⓖ (position: 12) is propargylglycine. Ⓚ (8) and Ⓖ (12) are cross-linked by hydrocarbon stapling by 1,3-diploar azide-alkyne cyclization

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetPseudomonas aeruginosa ATCC 27853

MethodMIC

PaperBeijun Liu, Wei Zhang, Sanhu Gou, Haifeng Huang, Jia Yao, Zhibin Yang, Hui Liu, Chao Zhong, Beiyin Liu, Jingman Ni, Rui Wang. Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity. J Pept Sci. 2017 Nov;23(11):824-832. Epub 2017 Aug 23. PMID28833783 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28833783/