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MYP_069243
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Basic Information
Ponericin W2
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
25 amino acids
C130H221N33O29
Standard
Sequence
WLGSALKIGAKLLPSVVGLFQKKKK
Physicochemical Analysis
2710.35 Da
10.70
5.75
5.54
0.2302
0.24
0.53
0.14
12.96
124.80
0.0800
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1008.39
-4.95
35.0
35.0
95.0
192.0
4.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016104 VERIFIED: YES
Provenance & Taxonomy
Neoponera goeldii [Animal]
Ponericin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic Anti-mammalian cells
PaperJ. Biol. Chem. 2001; 276: 17823-17829. PubMed. | http://www.ncbi.nlm.nih.gov/pubmed/11279030 PMID11279030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11279030/
RECORD: Rec_0035388 VERIFIED: YES
Provenance & Taxonomy
Pachycondyla goeldii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0043693 VERIFIED: YES
Provenance & Taxonomy
Neoponera goeldii [Animal]
NDBP
Structure & Mods
non-disulfide-bridged amphipathic peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Yeast Anti-Gram-negative Anti-Gram-positive Cytolytic Toxin Hemolytic Insecticidal
Gram-negative and Gram-positive bacteria
PaperThe Biochemical Toxin Arsenal from Ant Venoms PMID11279030;26805882 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11279030/
RECORD: Rec_0098579 VERIFIED: YES
Provenance & Taxonomy
Pachycondyla goeldii [Animal]
Ponericin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Insecticidal
Escherichia coli CIP 548, Escherichia coli L2, Enterobacter cloacae CIP 6085, Klebsiella pneumoniae CIP 8291, P. mirabilis LMA TP, S. enterica CIP 813, S. marcescens LMA TP, Y. entericolitica CIP 6529, A. faecalis CIP 6723, F. meningosepticum CIP 6057, Pseudomonas aeruginosa CIP A22, P. putida LMA, fungi Saccharomyces cerevisiae LMA 720, A. niger LMA 910
PaperPonericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. PMID11279030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11279030/
RECORD: Rec_0165693 VERIFIED: YES
Provenance & Taxonomy
Pachycondyla goeldii [Animal]; Insecta [Animal]
Ponericin
33208; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID11279030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11279030/
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