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MYP_069218
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Basic Information
Hyposin-HA4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
14 amino acids
C74H130N24O17
Standard
Sequence
FRPALIVRTKGTRL
Physicochemical Analysis
1627.97 Da
12.00
3.76
3.55
0.2685
0.01
0.24
-0.16
18.61
111.43
0.0714
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
685.01
-5.42
26.0
21.0
53.0
115.0
2.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0278940 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa azurea [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPubMed PMID: 17696382 PMID17696382 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17696382/
RECORD: Rec_0324960 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
PaperAmphibian skin secretomics: application of parallel quadrupole time-of-flight mass spectrometry and peptide precursor cDNA cloning to rapidly characterize the skin secretory peptidome of Phyllomedusa hypochondrialis azurea: discovery of a novel peptide family, the hyposins.
RECORD: Rec_0334498 VERIFIED: YES
Provenance & Taxonomy
Pithecopus azureus [Animal]
Hyposin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Non-hemolytic
PMID17696382;18644413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17696382/
RECORD: Rec_0338243 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa hypochondria [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperPatent US 10723764 B2 Evidence URLhttps://patents.google.com/patent/US10723764B2/en PatentUS 10723764 B2
RECORD: Rec_0379962 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Hyposin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Multifunction
CEM-SS
>61.4 μM
IC50
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
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