Peptide Database

Peptide NameACE inhibitory peptide

Function Ontology

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC68H132N36O16S

DescriptionStandard

        RRQRRRRMRKDK
    

Molecular Weight1742.07 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)7.76

Net Charge (pH 7.4) 7.55

Charge Density (pH 7.0) 0.6466

GRAVY Index-3.70

Hydrophobic Moment 0.33

Boman Index-1.82

Instability Index202.79

Aliphatic Index 0.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 949.15

LogP -11.67

H-bond Donors 38.0

H-bond Acceptors 25.0

Rotatable Bonds 67.0

Heavy Atoms 121.0

Ring Count 0.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0076527 VERIFIED: YES

Provenance & Taxonomy

OrganismPhaseolus vulgaris [Plant]

FamilyBioactive peptides

Tax ID3885

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

ACE inhibitory Antihypertensive

TargetAngiotensin-converting enzyme

Activity0.095 μM

MethodIC50

RECORD: Rec_0157887 VERIFIED: YES

Provenance & Taxonomy

OrganismPhaseolus vulgaris [Plant]

Tax ID3885.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antihypertensive ACE inhibitory

TargetAngiotensin-converting enzyme (ACE)

PaperMojica L., Chen K., de Mejia E.G.. Impact of Commercial Precooking of Common Bean (Phaseolus vulgaris) on the Generation of Peptides, After Pepsin-Pancreatin Hydrolysis, Capable to Inhibit Dipeptidyl Peptidase-IV. Journal of Food Science, 80, 188-198, DOI: 10.1111/1750-3841.12726. PMID25495131 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25495131/