Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length443 amino acids

Chemical FormulaC2245H3512N548O645S16

DescriptionStandard

        MVKICCSLLLLSLLSGQINANPGVKVRITQKGLEYAKEVGLEILKQNMEKEHFPDLSGYEKFGLGNVKYNISRIHVTAVEFPSASVSLIPGTGIKLVIGNASLTIDMNWNIRTWMFKDSGRGTVYISKVFVTAIFSTPLDNMGHTSISLTSCRTTSGDIDIKLNGKSGFLHNFFIKYLKKPIHRRLVANIGYFVLSTILTVLMSIDDLAEVDYSLNSLPAVFQPFIDLDLKGTVYPAGDYTGPPYVAAPFAIPDQSDSMLYLAFSEYFFQTSSFAYYTAGAFNITITEEVAKYSVIPYPVMLKLMATEVPIISLEEDSFTVEIQGSMEVFAVLPDSTTQSLFTMNITANTSIALNIFDQKLMGSLCLNRLQFSLAHSNVGFFEISLLENILSYILQTEVIPSANAKLSKGFPLPNLANVTLTRPHITIVQGYILISTDVHYKH
    

Molecular Weight49012.22 Da

Isoelectric Point (pI)6.00

Net Charge (pH 7.0)-4.72

Net Charge (pH 7.4) -5.56

Charge Density (pH 7.0) -0.0107

GRAVY Index0.26

Hydrophobic Moment 0.77

Boman Index0.21

Instability Index34.96

Aliphatic Index 105.39

Aromaticity 0.1061

Extinction Coeff. Reduced 39310.00

Extinction Coeff. Oxidized 39560.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0388631 VERIFIED: NO

Provenance & Taxonomy

OrganismPatagioenas fasciata monilis [Animal]

FamilyBPI/LBP

Tax ID372326

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria