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MYP_069122
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Basic Information
Caerin-1.7 [Cleaved into: Caerin-1.7.1]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C126H210N32O29
Standard
Sequence
GLFKVLGSVAKHLLPHVAPVIAEKL
Physicochemical Analysis
2637.21 Da
9.70
1.93
1.62
0.0774
0.88
0.59
0.36
19.91
152.00
0.0400
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
937.09
-3.31
31.0
33.0
85.0
187.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0293211 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Litoria xanthomera [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
Listeria innocua
50 μg/mL
MIC
PaperNew caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera.
RECORD: Rec_0318247 VERIFIED: YES
Provenance & Taxonomy
Litoria xanthomera [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
HIV inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells
2.5 μM
IC50
PaperPubMed PMID: 26026377 | PubMed PMID: 9230483 | PubMed PMID: 9204574 | PubMed PMID: 9516047 PMID26026377;9230483;9204574;9516047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0342823 VERIFIED: YES
Provenance & Taxonomy
Litoria xanthomera [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
100 μg/mL
MIC
PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0361142 VERIFIED: YES
Provenance & Taxonomy
Litoria xanthomera [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
12-50 μg/mL
MIC
PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0368568 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Litoria xanthomera [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
Streptococcus uberis
50 μg/mL
MIC
PaperNew caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera.
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