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MYP_069122
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Basic Information
Caerin-1.7 [Cleaved into: Caerin-1.7.1]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C126H210N32O29
Standard
Sequence
GLFKVLGSVAKHLLPHVAPVIAEKL
Physicochemical Analysis
2637.21 Da
9.70
1.93
1.62
0.0774
0.88
0.59
0.36
19.91
152.00
0.0400
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
937.09
-3.31
31.0
33.0
85.0
187.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0051291 VERIFIED: YES
Provenance & Taxonomy
Litoria xanthomera [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Cytotoxic
Human endocervical cells End1/E6E7:50% cell death at 12
PaperPubMed PMID: 26026377 | PubMed PMID: 9230483 | PubMed PMID: 9204574 | PubMed PMID: 9516047 PMID26026377;9230483;9204574;9516047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0060519 VERIFIED: YES
Provenance & Taxonomy
Litoria xanthomera [Animal]
Caerin
79697
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV Release inhibition
HIV | T cells
2.5 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of HIV infection by caerin 1 antimicrobial peptides. | VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA. | Peptides. 2015 Sep;71:296-303. | DOI:10.1016/j.peptides.2015.05.004 | PMID:26026377 PMID26026377 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0094899 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Litoria xanthomera [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
Lactococcus lactis
3 μM
MIC
PaperNew caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera.
RECORD: Rec_0100476 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Litoria xanthomera [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
Bacillus cereus
100 μg/mL
MIC
PaperNew caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera.
RECORD: Rec_0127708 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Litoria xanthomera [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
MIC 12.5-50 ug/ml, Staphylococcus epidermidis
50 μg/mL
MIC
PaperNew caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera.
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