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MYP_069080
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Basic Information
Exendin-4
Antimicrobial
Binding / Molecular interaction ▸ Binding activity
Cardiovascular
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Anti-diabetic
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Hypoglycemic
Regulatory peptide ▸ Biological regulation
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
39 amino acids
C184H281N49O61S
Standard
Sequence
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
Physicochemical Analysis
4187.56 Da
4.70
-3.14
-3.40
-0.0805
-0.69
0.71
0.01
64.08
52.56
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1743.96
-20.00
58.0
60.0
134.0
295.0
9.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0417944 VERIFIED: YES
Provenance & Taxonomy
Heloderma suspectum [Animal]
Exendin/GLP-1 receptor agonist
8554
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anti-diabetic
Human plasma, day 1 exenatide arm
ELISA
96 min
PaperPharmacokinetics and Preliminary Pharmacodynamics of Single- and Multiple-dose Lyophilized Recombinant Glucagon-like Peptide-1 Receptor Agonist (rE-4) in Chinese Patients with Type 2 Diabetes Mellitus PMIDreviewed_pmid=28932995
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