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MYP_069080
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Basic Information
Exendin-4
Antimicrobial
Binding / Molecular interaction ▸ Binding activity
Cardiovascular
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Anti-diabetic
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Hypoglycemic
Regulatory peptide ▸ Biological regulation
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
39 amino acids
C184H281N49O61S
Standard
Sequence
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
Physicochemical Analysis
4187.56 Da
4.70
-3.14
-3.40
-0.0805
-0.69
0.71
0.01
64.08
52.56
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1743.96
-20.00
58.0
60.0
134.0
295.0
9.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0369012 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
30 kDa PEG at Cys at 39th position
Bio-Activity Profile
Antihyperglycemic Metabolic regulation
stimulation of intracellular cAMP in PC12 cells
0.0142 μM
EC50
Intravenously injected into Sprague-Dawley rats at a dose of 5 µg·mL-1·kg-1, in vivo; 253800 s
PMID21244372 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21244372/
RECORD: Rec_0374983 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
5 kDa PEG at Cys at 39th position
Bio-Activity Profile
Antihyperglycemic Metabolic regulation
stimulation of intracellular cAMP in PC12 cells
0.0013 μM
EC50
Intravenously injected into Sprague-Dawley rats at a dose of 5 µg·mL-1·kg-1, in vivo; 21960 s
PMID21244372 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21244372/
RECORD: Rec_0378727 VERIFIED: YES
Provenance & Taxonomy
Heloderma horridum [Animal]
Exendin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
PEGylation
Addition of Fc
Bio-Activity Profile
Insulinotropic
EC50
blood; 223200 s
RECORD: Rec_0386224 VERIFIED: YES
Provenance & Taxonomy
Heloderma suspectum [Animal]
GLP-1 receptor agonist peptide
8554
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic Hypoglycemic GLP-1 receptor agonist
Mean terminal half-life is 2.4 h.
PaperPubMed-linked source references: PMID:25645567; PMID:25616979; PMID:25594949; PMID:25589020; PMID:17619527; PMID:16230722 PMID25645567;25616979;25594949;25589020;17619527;16230722 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25645567/ PatentUS6872700
RECORD: Rec_0391565 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Exendin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Receptor-binding
Radioimmunoassay
Rat plasma, in vitro; 8640 s
PMID21334413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21334413/
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