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MYP_069080
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Basic Information
Exendin-4
Antimicrobial
Binding / Molecular interaction ▸ Binding activity
Cardiovascular
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Anti-diabetic
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Hypoglycemic
Regulatory peptide ▸ Biological regulation
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
39 amino acids
C184H281N49O61S
Standard
Sequence
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
Physicochemical Analysis
4187.56 Da
4.70
-3.14
-3.40
-0.0805
-0.69
0.71
0.01
64.08
52.56
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1743.96
-20.00
58.0
60.0
134.0
295.0
9.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0280209 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Exendin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Receptor-binding
Radioactivity measurement
(Bolus injection)Pig kidney, in vivo; 1968 s
PMID23318502 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23318502/
RECORD: Rec_0332074 VERIFIED: YES
Provenance & Taxonomy
Heloderma suspectum [Animal]; synthetic construct [Synthetic]
GLP-1
8554;32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antidiabetic GLP-1 receptor agonist
Human GLP-1 receptor
Clinical/Human: 2.4 h
Evidence URLhttps://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021773s007lbl.pdf
RECORD: Rec_0333057 VERIFIED: NO
Provenance & Taxonomy
Heloderma suspectum [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone
RECORD: Rec_0344201 VERIFIED: YES
Provenance & Taxonomy
Heloderma suspectum [Animal]
Exendin/GLP-1 receptor agonist
8554
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anti-diabetic
Human plasma, day 84 exenatide arm
ELISA
108 min
PaperPharmacokinetics and Preliminary Pharmacodynamics of Single- and Multiple-dose Lyophilized Recombinant Glucagon-like Peptide-1 Receptor Agonist (rE-4) in Chinese Patients with Type 2 Diabetes Mellitus
RECORD: Rec_0362228 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 61.5%, E 0.0%, T 17.9%, C 20.5% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Drug Delivery Vehicle Blood-Brain Barrier
PaperBrainpeps: the blood-brain barrier peptide database PMID22205159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22205159/
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