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MYP_069080
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Basic Information
Exendin-4
Antimicrobial
Binding / Molecular interaction ▸ Binding activity
Cardiovascular
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Anti-diabetic
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Hypoglycemic
Regulatory peptide ▸ Biological regulation
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
39 amino acids
C184H281N49O61S
Standard
Sequence
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
Physicochemical Analysis
4187.56 Da
4.70
-3.14
-3.40
-0.0805
-0.69
0.71
0.01
64.08
52.56
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1743.96
-20.00
58.0
60.0
134.0
295.0
9.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0259088 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antihyperglycemic Metabolic regulation
stimulation of intracellular cAMP in PC12 cells
0.0014 μM
EC50
Intravenously injected into Sprague-Dawley rats at a dose of 5 µg·mL-1·kg-1, in vivo; 10440 s
PMID21244372 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21244372/
RECORD: Rec_0260651 VERIFIED: YES
Provenance & Taxonomy
Heloderma horridum [Animal]
Exendin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Addition of Fc
Pegylation at K27
Bio-Activity Profile
Insulinotropic
EC50
blood; 219600 s
RECORD: Rec_0267136 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
20 kDa PEG at Cys at 39th position
Bio-Activity Profile
Antihyperglycemic Metabolic regulation
stimulation of intracellular cAMP in PC12 cells
0.0012 μM
EC50
Intravenously injected into Sprague-Dawley rats at a dose of 5 µg·mL-1·kg-1, in vivo; 177840 s
PMID21244372 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21244372/
RECORD: Rec_0275330 VERIFIED: YES
Provenance & Taxonomy
Heloderma suspectum [Animal]
Exendin
8554
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Endocrine Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Feeding regulator
Experimental: 1.5 to 4 hours; /9900 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Exendin-4 (Heloderma suspectum): PMID 21244372 PMID21244372 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21244372/
RECORD: Rec_0278018 VERIFIED: YES
Provenance & Taxonomy
Heloderma suspectum [Animal]
Exendin/GLP-1 receptor agonist
8554
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anti-diabetic
Human plasma, day 8 exenatide arm
ELISA
78 min
PaperPharmacokinetics and Preliminary Pharmacodynamics of Single- and Multiple-dose Lyophilized Recombinant Glucagon-like Peptide-1 Receptor Agonist (rE-4) in Chinese Patients with Type 2 Diabetes Mellitus
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