‹ ›
MYP_069080
← PREVIOUS NEXT → BACK
Basic Information
Exendin-4
Antimicrobial
Binding / Molecular interaction ▸ Binding activity
Cardiovascular
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Anti-diabetic
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Hypoglycemic
Regulatory peptide ▸ Biological regulation
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
39 amino acids
C184H281N49O61S
Standard
Sequence
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
Physicochemical Analysis
4187.56 Da
4.70
-3.14
-3.40
-0.0805
-0.69
0.71
0.01
64.08
52.56
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1743.96
-20.00
58.0
60.0
134.0
295.0
9.0
40.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0119628 VERIFIED: YES
Provenance & Taxonomy
Heloderma horridum [Animal]
Exendin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Insulinotropic
EC50
blood; 2520 s
RECORD: Rec_0120065 VERIFIED: YES
Provenance & Taxonomy
Heloderma suspectum [Animal]
Exendin/GLP-1 receptor agonist
8554
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anti-diabetic Antihyperglycemic
Intestinal duodenum homogenate
Ultraviolet spectroscopy
103.08 min
PaperAn Investigation into the Gastrointestinal Stability of Exenatide in the Presence of Pure Enzymes, Everted Intestinal Rings and Intestinal Homogenates
RECORD: Rec_0123250 VERIFIED: YES
Provenance & Taxonomy
Heloderma suspectum [Animal]
Exendin/GLP-1 receptor agonist
8554
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anti-diabetic Antihyperglycemic
Intestinal jejunum homogenate
Ultraviolet spectroscopy
87.72 min
PaperAn Investigation into the Gastrointestinal Stability of Exenatide in the Presence of Pure Enzymes, Everted Intestinal Rings and Intestinal Homogenates
RECORD: Rec_0145479 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GLP-1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihyperglycemic Metabolic regulation
glucose -stimulated 1st phase insulin secretion in Exendin-4 -treated mice (20nmol/kg) is 1.62 fold higher than control
0.02 μM
LC-MS/MS
db/db Mice plasma (Dose i/v injected), in vivo; 10908 s
PMID25771000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25771000/
RECORD: Rec_0152125 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone replacement
Mean terminal half-life is 2.4 hours.
Evidence URLhttps://patents.google.com/patent/US5424286 PatentUS5424286
FIRST PREV 1 2 3 4 5 ... 8 NEXT LAST
Showing 5 records on this page · Page 3 of 8