Peptide Database

Peptide Name4309(derived from DNA-polymerase domain of HIV-1 RT (20-mers)),56(derived from the HIV-1 HXB2 Pol region of the viral genome)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC135H165N27O37

DescriptionStandard

        ETWETWWTEYWQATWIPEWE
    

Molecular Weight2757.91 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-5.15

Net Charge (pH 7.4) -5.33

Charge Density (pH 7.0) -0.2574

GRAVY Index-1.29

Hydrophobic Moment 0.34

Boman Index0.12

Instability Index-16.38

Aliphatic Index 24.50

Aromaticity 0.3500

Extinction Coeff. Reduced 34490.00

Extinction Coeff. Oxidized 34490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1032.91

LogP -1.41

H-bond Donors 37.0

H-bond Acceptors 32.0

Rotatable Bonds 76.0

Heavy Atoms 199.0

Ring Count 14.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389793 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Replication inhibition

Targetinhibition of strand transfer catalyzed by C130A integrase

Activity5 μM

MethodIC50

Half-LifeMammalian: 1 h; Yeast: 30 min; E. coli: >10 h

PaperInhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome. | Zawahir Z, Neamati N. | Bioorg Med Chem Lett. 2006 Oct 1;16(19):5199-202. | DOI:10.1016/j.bmcl.2006.07.022 | PMID:16879966 PMID16879966 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16879966/

RECORD: Rec_0405088 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

Targetinhibition of 3′-processing catalyzed by C130S integrase

Activity25 μM

MethodIC50

PaperPeptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase. J Biol Chem. 2005 Jun 10;280(23):21987-21996. doi: 10.1074/jbc.M414679200. PMID: 15790559 PMID15790559;16879966 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15790559/

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