Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length347 amino acids

Chemical FormulaC1715H2747N443O483S14

DescriptionStandard

        MSALSLLLVLLAVASTTLSVNPGVTVRLTDKGLQYGKQLGIAAMLDKLKSIQIPDFSGSLTVFLIGNVKYSLTNIRLVNVGLPRSAVTLVPGTGVRLTIGDAFMNLHGNWRLQYLRVIKNSGSFDVNINGLTISSSIVVESDETGRPVVSSTNCVANVASAKVKLHGGSCWFYIFFSMFINRAVQNGLQKQICPLLDKAVTCLNPKLQTLNVLAKVDKYAEIEYSMVSSPVISQSSIDLNLKGEFYNIGKHQESPFSPAAFSLPFQNNMLYMALSAFTANSAGFVYNKAGILSLYITNDMVPKGSPFQLNTKTFGVFIPQIAKQYPGLMMKLLVRAKKSPTITFQPK
    

Molecular Weight37748.74 Da

Isoelectric Point (pI)9.71

Net Charge (pH 7.0)15.72

Net Charge (pH 7.4) 15.22

Charge Density (pH 7.0) 0.0453

GRAVY Index0.25

Hydrophobic Moment 0.71

Boman Index0.17

Instability Index40.28

Aliphatic Index 104.47

Aromaticity 0.0893

Extinction Coeff. Reduced 27390.00

Extinction Coeff. Oxidized 27640.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0409392 VERIFIED: NO

Provenance & Taxonomy

OrganismPoeciliopsis prolifica [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria