Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length181 amino acids

Chemical FormulaC907H1435N257O240S12

DescriptionStandard

        PTAGAMAQEPMLLLAVTEHVANSATFTYFMAGALRRRISSHMFPQQFPIQLRTKSMRLLCAPQLQERYPDQPMELELWARQQSLVSCHPHALHRTLFGSAEAFVVLPNATRVPAFLLNIDANVTGKPRITRNRLGGTVKLTGGCLPCPVPQVKRLENLLKFGLWLFGVPWANSECCPHPVP
    

Molecular Weight20164.45 Da

Isoelectric Point (pI)9.64

Net Charge (pH 7.0)8.44

Net Charge (pH 7.4) 7.97

Charge Density (pH 7.0) 0.0466

GRAVY Index-0.01

Hydrophobic Moment 0.61

Boman Index0.08

Instability Index59.03

Aliphatic Index 88.95

Aromaticity 0.0773

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7822.51

LogP -85.25

H-bond Donors 272.0

H-bond Acceptors 266.0

Rotatable Bonds 639.0

Heavy Atoms 1416.0

Ring Count 41.0

Amide Bonds 197.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0112203 VERIFIED: NO

Provenance & Taxonomy

OrganismIndicator maculatus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria