Peptide Database

Peptide NameKalata B1 [W23WW]

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC128H197N37O41S6

DescriptionStandard

        GLPVCGETCVGGTCNTPGCTCSWWPVCTRN
    

Molecular Weight3102.55 Da

Isoelectric Point (pI)5.96

Net Charge (pH 7.0)-0.30

Net Charge (pH 7.4) -0.59

Charge Density (pH 7.0) -0.0099

GRAVY Index0.12

Hydrophobic Moment 0.31

Boman Index0.17

Instability Index45.37

Aliphatic Index 42.00

Aromaticity 0.0667

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1219.19

LogP -17.05

H-bond Donors 48.0

H-bond Acceptors 47.0

Rotatable Bonds 88.0

Heavy Atoms 212.0

Ring Count 7.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0021002 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

FamilyCyclotide

Tax ID32630

Structure & Mods

Configside-chain cyclized/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

RECORD: Rec_0074104 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

FamilyCyclotide

Tax ID32630

Structure & Mods

Configside-chain cyclized/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

TargetHuman erythrocytes

Activity14

MethodHemolysis

RECORD: Rec_0087269 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

FamilyCyclotide

Tax ID32630

Structure & Mods

Configside-chain cyclized/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetTumor cells: MM96L

Activity12.2±0.6 μM

MethodCC50

RECORD: Rec_0241159 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

FamilyCyclotide

Tax ID32630

Structure & Mods

Configside-chain cyclized/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetHeLa

Activity9.8±0.5 μM

MethodCC50

RECORD: Rec_0319973 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

FamilyCyclotide

Tax ID32630

Structure & Mods

Configside-chain cyclized/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic