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MYP_068804
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Basic Information
Urocortin
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Neurological / Signaling ▸ Neuropeptide activity ▸ Stress-related neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
40 amino acids
C204H336N62O65
Standard
Sequence
DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV
Physicochemical Analysis
4697.23 Da
5.58
-1.14
-1.40
-0.0285
-0.44
0.78
-0.16
48.38
109.75
0.0500
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2108.47
-22.59
74.0
65.0
160.0
331.0
4.0
44.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016837 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Sauvagine/corticotropin-releasing factor/urotensin I
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Stress-related neuropeptide
RECORD: Rec_0137852 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0202827 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Urocortin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Myotropic Receptor modulation Immunomodulatory ACE inhibitory Feeding regulator
Experimental: 54±3 minutes; /3240 seconds; Mammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Urocortin (Homo sapiens): PMID 15882144 PMID15882144 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15882144/
RECORD: Rec_0275639 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Natriuretic
Human blood plasma(Male patients with stable congestive heart failure) (Intravenous injection), in vivo; 3240 s
PMID15882144 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15882144/
RECORD: Rec_0299952 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
sauvagine/corticotropin-releasing factor/urotensin I family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone sauvagine corticotropin-releasing factor urotensin I family Neuropeptide signaling
PaperPDB 3N96 structural record; X-ray; 2.75 A; chain E/F/G/H; residues 25-40
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