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MYP_068782
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Basic Information
Brevinin-1GHd, Brevinin-1HL
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
24 amino acids
C116H196N28O28S2
Standard
Sequence
FLGALFKVASKLVPAAICSISKKC
Physicochemical Analysis
2495.10 Da
9.70
3.74
3.50
0.1557
1.11
0.53
0.32
8.76
122.08
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
888.60
-5.85
33.0
34.0
83.0
174.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0104937 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri,Hylarana latouchii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human squamous lung carcinoma NCI-H157
2.987 μM
IC50
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
RECORD: Rec_0105737 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri,Hylarana latouchii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Chromobacterium violaceum ATCC 12472
205.2 μM
MBC
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
RECORD: Rec_0108459 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri,Hylarana latouchii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human microvascular endothelial cells HMEC-1
15.62 μM
Cytotoxicity
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
RECORD: Rec_0144537 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus rugulosus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Anti-inflammatory
Pseudomonas aeruginosa
32 μM
MIC
PaperBrevinin-1GHd, A Novel Hylarana Guentheri Skin Secretion-Derived Brevinin-1 Type Peptide With Antimicrobial and Anticancer Therapeutic Potential
RECORD: Rec_0157266 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri,Hylarana latouchii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa ATCC 27853
32 μM
MBC
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
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