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MYP_068782
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Basic Information
Brevinin-1GHd, Brevinin-1HL
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
24 amino acids
C116H196N28O28S2
Standard
Sequence
FLGALFKVASKLVPAAICSISKKC
Physicochemical Analysis
2495.10 Da
9.70
3.74
3.50
0.1557
1.11
0.53
0.32
8.76
122.08
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
888.60
-5.85
33.0
34.0
83.0
174.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0055082 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Free
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: Staphylococcus aureus
2 μM
MIC
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
RECORD: Rec_0058051 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri,Hylarana latouchii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 43300
205.2 μM
MBC
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
RECORD: Rec_0058624 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri,Hylarana latouchii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human lung adenocarcinoma NCI-H23
8.52
IC50
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
RECORD: Rec_0064809 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri,Hylarana latouchii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus NCTC 12493
4 μM
MBC
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
RECORD: Rec_0099085 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Free
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
Brevinin-1GHd
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
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