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MYP_068782
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Basic Information
Brevinin-1GHd, Brevinin-1HL
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
24 amino acids
C116H196N28O28S2
Standard
Sequence
FLGALFKVASKLVPAAICSISKKC
Physicochemical Analysis
2495.10 Da
9.70
3.74
3.50
0.1557
1.11
0.53
0.32
8.76
122.08
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
888.60
-5.85
33.0
34.0
83.0
174.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001381 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri,Hylarana latouchii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human glioblastoma U251-MG
7.985 μM
IC50
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
RECORD: Rec_0007391 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri,Hylarana latouchii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human prostate adenocarcinoma PC-3
9.854 μM
IC50
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
RECORD: Rec_0010166 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Free
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-negative:Escherichia coli
8 μM
MIC
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
RECORD: Rec_0010245 VERIFIED: YES
Provenance & Taxonomy
Sylvirana guentheri,Hylarana latouchii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus NCTC 10788
4 μM
MBC
PMID32347293 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32347293/
RECORD: Rec_0031802 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus rugulosus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Anti-inflammatory
Escherichia coli
8 μM
MIC
PaperBrevinin-1GHd, A Novel Hylarana Guentheri Skin Secretion-Derived Brevinin-1 Type Peptide With Antimicrobial and Anticancer Therapeutic Potential
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