Peptide Database

Peptide NameDermaseptin-4 (DStar 04; Frogs, amphibians, animals)

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length23 amino acids

Chemical FormulaC115H192N32O33

DescriptionStandard

        ALWKDILKNAGKAALNEINQIVQ
    

Molecular Weight2550.95 Da

Isoelectric Point (pI)8.54

Net Charge (pH 7.0)0.80

Net Charge (pH 7.4) 0.60

Charge Density (pH 7.0) 0.0346

GRAVY Index-0.05

Hydrophobic Moment 0.69

Boman Index0.09

Instability Index22.26

Aliphatic Index 131.74

Aromaticity 0.0435

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1087.42

LogP -8.68

H-bond Donors 35.0

H-bond Acceptors 34.0

Rotatable Bonds 89.0

Heavy Atoms 180.0

Ring Count 2.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0412864 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa sauvagii [Animal]

FamilyDermaseptin

Tax ID8395

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anticancer

TargetCandida albicans NCYC 1467

Activity64 μM

MethodMIC

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