Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length529 amino acids

Chemical FormulaC2625H4190N668O747S21

DescriptionStandard

        MTATPTFAPLTVGMQLFFSYPTPPVCLRQKQRQRTKALLRHFKVRVDMVSLWCVLALLSFLSPEASGINPGVKVRLTEKGLEYGRQIGLIALQKKFKTIKIPDMSGSVKVSPIGKVSYSLTNIQILNLGLPKSAVGLAPGTGVSLSISDAYINLHGNWRVKYHKLIKDKGSFDLSVSGLSISATIGVKGDDTGRPMVSSVNCAASVGQVNVKFHGGASWLYNLFKHYIDKALRSALQKQICSLVGEAIDEMNPHLKTLNVLAQVDKYAEIEYSMVESPLISDSSIDLSLKGEFYNIGQHKEPPFSPTPISLPAQDSNMLYIGLSAFTLNSAGFVYNNAGVLSLYVTDDMIPSSFPIRLNTRTFGTFIPQIAKQYPGLMMKLLVKAVKEPNISFEPNNMTMQASSTVTAYAIQPNATLTPLFVLNVNASVSAQIYVSGLKVAGDLSLNEMDMTLVTSYVGPFQVKSLDSVLSMILKVVVIPKVNAYLKQGYPLPAIGKMNLLNTQLQILKDYVLIGTDVQFTGWALPDVY
    

Molecular Weight57732.74 Da

Isoelectric Point (pI)9.34

Net Charge (pH 7.0)14.07

Net Charge (pH 7.4) 13.32

Charge Density (pH 7.0) 0.0266

GRAVY Index0.16

Hydrophobic Moment 0.71

Boman Index0.16

Instability Index30.70

Aliphatic Index 103.71

Aromaticity 0.0851

Extinction Coeff. Reduced 53290.00

Extinction Coeff. Oxidized 53540.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0379242 VERIFIED: NO

Provenance & Taxonomy

OrganismPangasianodon hypophthalmus [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence