Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length341 amino acids

Chemical FormulaC1724H2692N478O486S9

DescriptionStandard

        MMARLYCVVVTLLLLAEVSGFEEGATNPGVVARITRKGLAYARQLGVAILKKELSTIKLPDFSGSFKVSWIKTVSYDFYRLTIHRFELRNSDLRLRPRQGVRASLSNNYMFVSGNWKVKKAFVTLDGTFDVNVDGISISVSLNLGKDQSGRPTASVAHCRNSIGHISVDISGQLSWILNLLHKRIENNFKNILEQKIREMVRKSTTSHLEPYLRTPPVSSRIDQVAGIDYSLVGAPKVTSQVLDTPFKEPWEGDVSFCLQGEFFGQNWHSPALFDAPPIRLPEKHDHMVYFAVSEYVFNTASRVYHQAGLMNFTIQNHHIPPGLSNPPAHQLIPGHYSSAG
    

Molecular Weight38179.31 Da

Isoelectric Point (pI)9.42

Net Charge (pH 7.0)9.63

Net Charge (pH 7.4) 8.64

Charge Density (pH 7.0) 0.0282

GRAVY Index-0.16

Hydrophobic Moment 0.75

Boman Index0.05

Instability Index35.32

Aliphatic Index 91.14

Aromaticity 0.0968

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44015.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0300018 VERIFIED: NO

Provenance & Taxonomy

OrganismCallorhinus ursinus [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence