Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length472 amino acids

Chemical FormulaC2319H3715N587O670S21

DescriptionStandard

        MFLCCWLGLVALIPTTLSTNPGVKVRLTEKGIEYGRQLGMAVIQQKLRSIKIPDFSGTETVSPIGKVQYSLSNMHIVNVGLPKSSVDLVPGTGVTLSIGDAFISLNGNWRVKYLRIIKDSGSFDLNVNGLSIATTISIKSDETGRPAVSTASCSATVGSAKVKFHGGASWLYNLFTTFIDKALRNALQKQICPLVADAVSDLNPQLKTLNVLAKVDKYAEIEYSMVSSPTVLKSSIDLSLKGEFYNIGKHQEPPFSPAAFYLPPQNNNMLYIGMSAFTVNSAAFVYNNAGVLSLSVTDDMIPKSSPIRLNTKTFGAFIPQIAKQFPGLMMKLLMKMEKIPTLTFEPNNATVQATTTVTAFAIQTNSTLSPLFVLNLEASVSARMFVSEMKLAAAVTLNKMDLTLAKSYVGDFQVGPLENVFQGVLKWVVIPTVNAQLAKGYPLPSIGKMKLMNTQLDVLKDYMLIGTDVQFS
    

Molecular Weight51212.20 Da

Isoelectric Point (pI)9.28

Net Charge (pH 7.0)10.73

Net Charge (pH 7.4) 10.20

Charge Density (pH 7.0) 0.0227

GRAVY Index0.20

Hydrophobic Moment 0.72

Boman Index0.17

Instability Index32.11

Aliphatic Index 100.36

Aromaticity 0.0826

Extinction Coeff. Reduced 41370.00

Extinction Coeff. Oxidized 41620.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0287392 VERIFIED: NO

Provenance & Taxonomy

OrganismOreochromis niloticus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence