Peptide Database

Peptide NameHumidimycin

Function Ontology

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC98H138N22O28S4

DescriptionStandard

        CLGIGSCDDFAGCGYAIVCFW
    

Molecular Weight2200.53 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-2.28

Net Charge (pH 7.4) -2.54

Charge Density (pH 7.0) -0.1085

GRAVY Index1.17

Hydrophobic Moment 0.31

Boman Index0.51

Instability Index38.95

Aliphatic Index 79.05

Aromaticity 0.1905

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7240.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 776.17

LogP -5.73

H-bond Donors 31.0

H-bond Acceptors 30.0

Rotatable Bonds 65.0

Heavy Atoms 152.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0112179 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces humidus [Bacterium]

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Other Modsidentified from the screening of a collection of 20,000 microbial extracts. Sequence analysis: APD analysis reveals that this sequence is similar (95.24%) to Siamycin II C=G: 19%; I=F=A=D: 10%. GRAVY: 1.17; mol Wt: 2200.573; mol formula: C98H139N22O28S4; mol ex coeff: 7290. Chemical modification: cyclized from the side chain of Asp9 to the N-terminus of Cysl. Two disulfide bonds: C1-C13 and C7-C19, lleading to a tricyclic structure. Last W is a D-amino acid (SÃ¡nchez-Hidalgo et al., 2020)

Bio-Activity Profile

Function

Antifungal

Targetthe growth of A. fumigatus