Peptide Database

Peptide NameSLAY-screened peptide P2940

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC109H154N28O30S2

DescriptionStandard

        YCPAKSDLDYSARPVFHYHM
    

Molecular Weight2400.69 Da

Isoelectric Point (pI)6.91

Net Charge (pH 7.0)-0.08

Net Charge (pH 7.4) -0.40

Charge Density (pH 7.0) -0.0039

GRAVY Index-0.58

Hydrophobic Moment 0.47

Boman Index-0.02

Instability Index76.16

Aliphatic Index 44.00

Aromaticity 0.2000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 919.67

LogP -6.61

H-bond Donors 33.0

H-bond Acceptors 34.0

Rotatable Bonds 70.0

Heavy Atoms 169.0

Ring Count 8.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0158010 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/