Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length522 amino acids

Chemical FormulaC2668H4179N669O757S17

DescriptionStandard

        MMCTKMVQVLWGCFLLWNLYISSAQTIYPGIKARATQRALDYGIQAGVEMIEQMVKERNIPDLKGSESPEFLKIDYMNYKLINIKINAFSLPNTSLAFVPGVGIRALIKHGTANISTDWEIKSPLFQDTGGANLLLSGVYFTGIVVLARNDFGHPILKLQDCNAQVSHNDISFSGELSVLYNSFAEPMEKPILKNLNKMLCPIITSEVEALNANLSTLEVLRSIDNYTLLDYSLVSSPEITENYIDLNLKGVFYPLENLTDPPFSSVPFVLPEHSDSMIYVGISEYFFKSASYAYFTAGAFNVTLTTKKIFNNLIRNSQGLGNMLSWIAELYILSQPFMVQVLAREPPVVNLLPGNFTLDIPASFVILTQSKNSTAETIISMDFVASTNVALAILGQRLICSLSLNRFRLSLPESIRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSLKQQPSFHGWEVLNLISGQWRGKPAPWLPVWSPLQEVNRP
    

Molecular Weight58283.85 Da

Isoelectric Point (pI)5.89

Net Charge (pH 7.0)-4.89

Net Charge (pH 7.4) -5.65

Charge Density (pH 7.0) -0.0094

GRAVY Index0.15

Hydrophobic Moment 0.73

Boman Index0.17

Instability Index44.46

Aliphatic Index 108.31

Aromaticity 0.0996

Extinction Coeff. Reduced 69330.00

Extinction Coeff. Oxidized 69580.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0277627 VERIFIED: NO

Provenance & Taxonomy

OrganismMonodon monoceros [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence