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MYP_068349
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Basic Information
Peptide2
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
18 amino acids
C94H138N26O38S
Standard
Sequence
QDKHEEDYQMYNKGDKED
Physicochemical Analysis
2272.32 Da
4.49
-4.14
-4.41
-0.2301
-2.83
0.34
-0.64
71.82
0.00
0.1111
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1095.59
-11.83
35.0
36.0
81.0
159.0
3.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0095310 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 34328726 PMID34328726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34328726/
RECORD: Rec_0282662 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Entry inhibition
SARS-CoV-2 | HEK293T/ACE2 cells
0.018±0.002 μM
IC50
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperSynthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein | Sadremomtaz A, Al-Dahmani ZM, Ruiz-Moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-Velázquez MA, de Jong D, de Jonge J, Smit J, Dömling A, van Goor H, Groves MR. | J Med Chem. 2022 Feb 24;65(4):2836-2847. | DOI:10.1021/acs.jmedchem.1c00477 | PMID:34328726 PMID34328726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34328726/
RECORD: Rec_0311067 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV-2:Inhibition of virus entry in HEK293T/ACE2 cells (via inhibition of SRBD:ACE2 interaction)
18±2 μM
IC50
PaperPubMed PMID: 34328726 PMID34328726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34328726/