‹ ›
MYP_068125
← PREVIOUS NEXT → BACK
Basic Information
JEV Ep (418452)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
35 amino acids
C164H244N46O46
Standard
Sequence
AALGDTAWDFGSIGGVFNSIGRAVHQVFGGAFRTL
Physicochemical Analysis
3595.97 Da
6.79
-0.11
-0.35
-0.0033
0.47
0.76
0.31
5.74
83.71
0.1429
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1462.69
-15.42
52.0
47.0
113.0
256.0
7.0
36.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0024911 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Japanese encephalitis virus (JEV)
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0121436 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Japanese encephalitis virus (JEV):inhibition of JEV infection in BHK-21 (baby hamster kidney) cells
0.05807 μM
IC50
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0122451 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-JEV Entry inhibition
Japanese encephalitis virus (JEV)
0.05807 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperAntiviral activity of peptide inhibitors derived from the protein E stem against Japanese encephalitis and Zika viruses. | Chen L, Liu Y, Wang S, Sun J, Wang P, Xin Q, Zhang L, Xiao G, Wang W. | Antiviral Res. 2017 May;141:140-149. | DOI:10.1016/j.antiviral.2017.02.009 | PMID:28232248 PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0406776 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Baby Hamster Kidney cells BHK-21
25 % Cell death
Cell death
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/