Peptide Database

Peptide NameRNS2_PYRPY

Function Ontology

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Neurological / Signaling ▸ Signaling peptide

Other / Curated residual function label ▸ Generic enzyme inhibition annotation

Standard StatusStandard

Sequence Length221 amino acids

Chemical FormulaC1157H1796N316O323S14

DescriptionStandard

        FWRKQWYKHGSCASPALPNQKHYFETVIRMFLAEKQNVSRILSMATIEPEGKNRTLLEIQNAIRAGTNNMIPKLKCQKVNGMTELVEVTLCHDSNLTQFILFTVHGLWPSTKVGRDPEYCKTKRYRKIQRLEPQLEIIWPNVSDRKANRGMIYIFTMVFSLNVLILSSSAARYDYFQFTQQYQQAFCNSNPTPCKDPPDKNCPRPLPQASPYFCPIDDIQY
    

Molecular Weight25749.47 Da

Isoelectric Point (pI)9.26

Net Charge (pH 7.0)10.04

Net Charge (pH 7.4) 9.46

Charge Density (pH 7.0) 0.0454

GRAVY Index-0.47

Hydrophobic Moment 0.72

Boman Index-0.05

Instability Index37.08

Aliphatic Index 74.57

Aromaticity 0.1131

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37400.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0043400 VERIFIED: YES

Provenance & Taxonomy

OrganismPyrus pyrifolia [Plant]; Pyrus serotina [Plant]

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Signaling Enzyme inhibitory ACE inhibitory Antihypertensive

TargetAngiotensin-converting enzyme