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MYP_067998
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Basic Information
Brevinin-1HY
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C113H187N27O25S2
Standard
Sequence
FALGAVTKVLYKLFCLITRKC
Physicochemical Analysis
2387.99 Da
9.70
3.74
3.50
0.1779
1.10
0.63
0.27
2.52
130.00
0.1429
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
845.97
-2.99
33.0
31.0
79.0
167.0
3.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0231214 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human colon adenocarcinoma HCT 116
3.583 μM
IC50
PMID32812694 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32812694/
RECORD: Rec_0237827 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Amolops hainanensis [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
NCI-H157
2.811 μM
IC50
PaperPubMed PMID: 32812694 PMID32812694 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32812694/
RECORD: Rec_0239018 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Amolops hainanensis [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 32812694 PMID32812694 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32812694/
RECORD: Rec_0244645 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human prostate adenocarcinoma PC-3
5.425 μM
IC50
PMID32812694 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32812694/
RECORD: Rec_0245898 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Klebsiella pneumoniae ATCC 43816
128 μM
MBC
PMID32812694 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32812694/
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