Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2320H3750N608O660S17

DescriptionStandard

        MSALSLLLVLLAVASTTLSVNPGVTVRLTDKGLQYGKQLGIAAMQEKLKSIQIPDFSGSERVSPIGKVQYSLTNIRLVNVGLPRSAVALVPGTGVRLTIGDAFMNLNGNWRVKYLRIIKDSGSFDVNVNGLTISTSVVVKSDATGRPVVSSTNCVANVASAKVKFHGGASWLYNLFSKFINKALRNALQKQICPLVDKTVTGLNPKLQTLNVLAKVDKYAEIEYSMVSSPVISQSSLDLNLKGQFYNIGKHQEPPFTPVAFSLPPQNNNMLYMGLSAFTANSAGFVYNKAGVLSLYITDDMVPKGSPFRLNTKTFGVFIPQIAKQYPGLMMKLLLRAKNSPTITFQPKNATAVATATMAAYAIQPNGTLSPLFVLNLESSVSADVYVRGLNIAGRLTLNQMKLSVGTSYVGQFQVGVLDSVLRMVLKVIVIPIVNVQFDKGYPLPALGKMNLVNPQLQIMKDYMLIGTDVNFTD
    

Molecular Weight51265.37 Da

Isoelectric Point (pI)9.84

Net Charge (pH 7.0)21.65

Net Charge (pH 7.4) 21.21

Charge Density (pH 7.0) 0.0457

GRAVY Index0.21

Hydrophobic Moment 0.83

Boman Index0.16

Instability Index33.77

Aliphatic Index 105.84

Aromaticity 0.0781

Extinction Coeff. Reduced 34840.00

Extinction Coeff. Oxidized 34965.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0042148 VERIFIED: NO

Provenance & Taxonomy

OrganismXiphophorus maculatus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence