Peptide Database

Peptide NameBeta-defensin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length79 amino acids

Chemical FormulaC382H600N104O112S9

DescriptionStandard

        MKTFLFLFAVLFFLDPAKNAFFDEKCSRVNGRCTASCLKNEELVALCQKNLKCCVTVQPCGKSKSNQSDEGSGHMGTWG
    

Molecular Weight8730.06 Da

Isoelectric Point (pI)8.53

Net Charge (pH 7.0)2.52

Net Charge (pH 7.4) 2.14

Charge Density (pH 7.0) 0.0320

GRAVY Index-0.11

Hydrophobic Moment 0.50

Boman Index0.02

Instability Index26.38

Aliphatic Index 64.18

Aromaticity 0.1013

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5875.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3500.09

LogP -37.74

H-bond Donors 126.0

H-bond Acceptors 125.0

Rotatable Bonds 294.0

Heavy Atoms 607.0

Ring Count 12.0

Amide Bonds 86.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0000161 VERIFIED: NO

Provenance & Taxonomy

OrganismMus spicilegus [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-stabilized peptide with linear backbone [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin

MethodQualitative functional evidence

RECORD: Rec_0253621 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyBeta-defensin; Defensin

Tax ID10090

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Non-hemolytic