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MYP_067928
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Basic Information
Circulin D
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Standard
31 amino acids
C154H240N40O44S6
Standard
Sequence
KIPCGESCVWIPCVTSIFNCKCKENKVCYHD
Physicochemical Analysis
3548.18 Da
7.77
0.79
0.44
0.0256
-0.02
0.41
0.04
14.86
65.81
0.0968
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1346.29
-12.01
51.0
52.0
113.0
244.0
7.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037148 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
50-275
EC50
PMID10691702 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
RECORD: Rec_0058972 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 10691702 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10691702;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
RECORD: Rec_0081221 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0132643 VERIFIED: YES
Provenance & Taxonomy
Chassalia kolly [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0181816 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antiviral Anti-HIV
HIV
PMID10691702 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
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