Peptide Database

Peptide NameKisspeptin-10

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Reproductive neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Cell-cell communication

Reproductive biology ▸ Reproductive modulation

Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-aging

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC63H82N16O15

DescriptionStandard

        YNWNSFGLRF
    

Molecular Weight1303.42 Da

Isoelectric Point (pI)8.75

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0759

GRAVY Index-0.55

Hydrophobic Moment 0.40

Boman Index0.07

Instability Index30.23

Aliphatic Index 39.00

Aromaticity 0.4000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 529.55

LogP -3.40

H-bond Donors 19.0

H-bond Acceptors 16.0

Rotatable Bonds 38.0

Heavy Atoms 94.0

Ring Count 5.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0063219 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyKISS1

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPhosphotyrosine

C-TermAmidation

Bio-Activity Profile

Function

Hormone Reproductive neuropeptide

RECORD: Rec_0111087 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyKisspeptin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Other Mods1:Phosphotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Reproductive regulator Receptor modulation ACE inhibitory

Half-LifeMammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min

RECORD: Rec_0122257 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cell-Cell Communication

RECORD: Rec_0319378 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyKisspeptin-derived peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-aging

TargetHuman skin tissue from a woman donor of 38 years of age (Ex vivo)

MethodELISA; Immunostaining; qRT-PCR

RECORD: Rec_0420560 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyKisspeptin-derived peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-aging

TargetHuman dermal fibroblast (Hs68) (In vitro)

MethodELISA; Immunostaining; qRT-PCR