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MYP_067711
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Basic Information
Desotamide B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
6 amino acids
C34H52N8O8
Standard
Sequence
WLLVNG
Physicochemical Analysis
700.83 Da
5.53
-0.24
-0.44
-0.0400
1.17
0.15
0.62
3.85
178.33
0.1667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
267.70
-0.20
9.0
8.0
20.0
50.0
2.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0256151 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. [Bacterium]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: NCI-H460 (Not active up to 30 μM)
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0261760 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp.,Streptomyces scopuliridis SCSIO ZJ46 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human hepatocellular carcinoma HepG2
329 μM
IC50
PMID25229313;29431987;25072108;29125222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0267575 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp.,Streptomyces scopuliridis SCSIO ZJ46 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli deltatolC
200 μg/mL
MIC
PMID25229313;29431987;25072108;29125222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0291265 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp.,Streptomyces scopuliridis SCSIO ZJ46 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus epidermidis ATCC 14990
200 μg/mL
MIC
PMID25229313;29431987;25072108;29125222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0311223 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp.,Streptomyces scopuliridis SCSIO ZJ46 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 11775
30 μM
IC50
PMID25229313;29431987;25072108;29125222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
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