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MYP_067711
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Basic Information
Desotamide B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
6 amino acids
C34H52N8O8
Standard
Sequence
WLLVNG
Physicochemical Analysis
700.83 Da
5.53
-0.24
-0.44
-0.0400
1.17
0.15
0.62
3.85
178.33
0.1667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
267.70
-0.20
9.0
8.0
20.0
50.0
2.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002862 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp.,Streptomyces scopuliridis SCSIO ZJ46 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Enterococcus faecium ATCC 19434
100 μg/mL
MIC
PMID25229313;29431987;25072108;29125222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0005397 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp.,Streptomyces scopuliridis SCSIO ZJ46 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 9144
30 μM
IC50
PMID25229313;29431987;25072108;29125222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0016480 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0022925 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp.,Streptomyces scopuliridis SCSIO ZJ46 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Bacillus subtilis ATCC 6051
4.3 μM
IC50
PMID25229313;29431987;25072108;29125222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0026617 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp.,Streptomyces scopuliridis SCSIO ZJ46 [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human colon adenocarcinoma SW620
PMID25229313;29431987;25072108;29125222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
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