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MYP_067700
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Basic Information
Cryptdin-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
35 amino acids
C168H287N61O46S7
Standard
Sequence
LRDLVCYCRSRGCKGRERMNGTCRKGHLLYTLCCR
Physicochemical Analysis
4121.91 Da
9.61
6.79
6.44
0.1939
-0.55
0.43
-0.36
16.85
64.00
0.0571
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1785.58
-20.44
74.0
61.0
141.0
282.0
3.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016589 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperOuellette J. A., Satchell. Characterization of luminal paneth cell alpha-defensins in mouse small intestine. J. Biol. Chem., 275, 43, 33969-33973.
RECORD: Rec_0049647 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Attenuated species of Salmonella typhimurium
PMID1500431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1500431/
RECORD: Rec_0101235 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0257460 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
6-34; 8-23; 13-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Listeria monocytogenes EGD
PaperPubMed PMID: 1500431 PMID1500431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1500431/
RECORD: Rec_0269484 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
6-34; 8-23; 13-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
mouse-avirulent Salmonella typhimurium 7953
PaperPubMed PMID: 1500431 PMID1500431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1500431/
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