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MYP_067699
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Basic Information
Hl Defensin-2, HlDFS2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
36 amino acids
C165H265N59O46S6
Standard
Sequence
GFGCPLNQGACHRHCRSIRRRGGYCSGIIKQTCTCY
Physicochemical Analysis
4003.63 Da
9.43
5.87
5.48
0.1631
-0.44
0.82
-0.16
90.88
46.11
0.0833
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1716.56
-22.89
69.0
60.0
130.0
276.0
6.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0210499 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human myelogenous leukemia K562
PMID28969703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28969703/
RECORD: Rec_0231174 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus CMCC 26003
>50 μM
PMID28969703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28969703/
RECORD: Rec_0231744 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli CMCC 44103
1 μM
MIC50
PMID28969703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28969703/
RECORD: Rec_0243917 VERIFIED: YES
Provenance & Taxonomy
Haemaphysalis longicornis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
50 μM
MIC
RECORD: Rec_0247255 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
(Not active up to 20 μM)
PaperPubMed PMID: 28969703 PMID28969703 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28969703/
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