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MYP_067572
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Basic Information
Rev (34-50) -A4C
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
22 amino acids
C112H198N56O29S
Standard
Sequence
TRQARRNRRRRWRERQRAAAAC
Physicochemical Analysis
2825.19 Da
12.00
8.39
8.18
0.3814
-2.23
0.47
-1.11
182.82
22.73
0.0455
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1496.01
-20.38
60.0
39.0
98.0
198.0
2.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0397553 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 IIIB | PM1-CCR5 cells
0.35±0.07 μM
EC50
Mammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h
PaperRev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4. | Shimane K, Kodama EN, Nakase I, Futaki S, Sakurai Y, Sakagami Y, Li X, Hattori T, Sarafianos SG, Matsuoka M. | Int J Biochem Cell Biol. 2010 Sep;42(9):1482-8. | DOI:10.1016/j.biocel.2010.05.005 | PMID:20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
RECORD: Rec_0416598 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/
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