Peptide Database

Peptide NameTP1[C3A, C16S] (Derived from TP1)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC99H154N34O21S2

DescriptionStandard

        KWAFRVCYRGICYRRSR
    

Molecular Weight2220.63 Da

Isoelectric Point (pI)10.90

Net Charge (pH 7.0)5.74

Net Charge (pH 7.4) 5.50

Charge Density (pH 7.0) 0.3375

GRAVY Index-0.75

Hydrophobic Moment 0.68

Boman Index-0.45

Instability Index41.56

Aliphatic Index 45.88

Aromaticity 0.2353

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 940.92

LogP -7.33

H-bond Donors 40.0

H-bond Acceptors 29.0

Rotatable Bonds 71.0

Heavy Atoms 156.0

Ring Count 5.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0425148 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic

Targetcells at the highest tested concentration, 100 μg/ml

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