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MYP_067262
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Basic Information
Hepcidin (Liver-expressed antimicrobial peptide 1) (LEAP-1) (Putative liver tumor regressor) (PLTR) [Cleaved into: Hepcidin-25 (Hepc25); Hepcidin-20 (Hepc20)]
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
84 amino acids
C405H655N123O109S13
Standard
Sequence
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT
Physicochemical Analysis
9408.14 Da
9.24
6.59
6.13
0.0784
0.14
0.52
0.03
79.20
77.98
0.0714
11000.00
11500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3715.70
-38.48
141.0
131.0
308.0
650.0
14.0
90.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0031974 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
S. epidermidis (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID11113131;11034317;12975309;15057824;15489334;12010514;15124018;22306005;22682227;29237594;12138110;19553669;32814342;14633868;12915468;14630809;14670915;15099344 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11113131/
RECORD: Rec_0103639 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://patents.google.com/patent/US20060093596A1/en PatentUS 2006/0093596 A1
RECORD: Rec_0194593 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus aureus (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID11113131;11034317;12975309;15057824;15489334;12010514;15124018;22306005;22682227;29237594;12138110;19553669;32814342;14633868;12915468;14630809;14670915;15099344 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11113131/
RECORD: Rec_0201599 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Pseudomonas aeruginosa (Gram-negative)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID11113131;11034317;12975309;15057824;15489334;12010514;15124018;22306005;22682227;29237594;12138110;19553669;32814342;14633868;12915468;14630809;14670915;15099344 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11113131/
RECORD: Rec_0314416 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Escherichia coli (Gram-negative)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID11113131;11034317;12975309;15057824;15489334;12010514;15124018;22306005;22682227;29237594;12138110;19553669;32814342;14633868;12915468;14630809;14670915;15099344 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11113131/
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