Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length532 amino acids

Chemical FormulaC2721H4264N698O753S18

DescriptionStandard

        MGNRSCPPPPAPTAAFLLPLSTTALPFPRRLLYRSQVPIRGLEVWAALEDMTWGPDNVRKWSALALLAIIGTALTAATDPGFVAMISQKGLDFACQQGVVELQKELQTISVPDFSGVFKIKHLGKGSYEFYSMAVDGFHIPNPEIEMLPSDGLRLFIKDASIKINGKWMSRKNFLKAGGNFELSIQGVSISTDLILGSDSSGHITTICSNCDSHIDSVHIKISGSVLGWLIRLFHRKIETSLKNIIYKKICKIVRNSVSSKLQPYLKTLSVISRVDDVTSVDYSLVDSLTTTNQFLEGQLKGEFFWRGHRGPLPIHPPVMRFVPNSAYMVCMGISDYFFNTAVFAYQQSGTLKVTLGSQLLLNDGRFQLNTDFLRTFLPQVARKFPSMGVQLLISAPEPEHLSIQPTGLSFNPRLETQAFVVLPNASLVPLFVLSMKTNASLEVDAEENRLVGEMKFGKWLLELKESKFGPFKVEYLEDVINYLVPTLVLPKINERLRRGFPLPLPAGIQFSDFTFYPYQNFLLLEADLHLI
    

Molecular Weight59380.36 Da

Isoelectric Point (pI)8.70

Net Charge (pH 7.0)5.36

Net Charge (pH 7.4) 4.44

Charge Density (pH 7.0) 0.0101

GRAVY Index0.08

Hydrophobic Moment 0.86

Boman Index0.13

Instability Index37.22

Aliphatic Index 100.39

Aromaticity 0.1015

Extinction Coeff. Reduced 57870.00

Extinction Coeff. Oxidized 58245.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0311804 VERIFIED: NO

Provenance & Taxonomy

OrganismMus caroli (Ryukyu mouse) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria