Peptide Database

Peptide NameAscaphin-8-4

Function Ontology

Anticancer

Anticancer ▸ Antitumor

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC99H168N26O23

DescriptionStandard

        GFKDLLKGRAKALVKSVLF
    

Molecular Weight2090.55 Da

Isoelectric Point (pI)10.46

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.1977

GRAVY Index0.40

Hydrophobic Moment 0.39

Boman Index0.07

Instability Index-8.89

Aliphatic Index 123.16

Aromaticity 0.1053

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 810.63

LogP -4.34

H-bond Donors 29.0

H-bond Acceptors 27.0

Rotatable Bonds 74.0

Heavy Atoms 148.0

Ring Count 2.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0260869 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Anticancer Antitumor

TargetC4-2B

Activity17.26 μM

MethodIC50

RECORD: Rec_0357129 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Hemolytic

Targetrabbit RBCs

Activity95.46 μM

MethodHC50

RECORD: Rec_0418301 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Anticancer Antitumor

TargetHEK293T

Activity44.28 μM

MethodIC50

RECORD: Rec_0421857 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAscaphin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Modscross-linked by ring-closing metathesis, potential anti-tumor peptide; Hydrocarbon staple / ring-closing metathesis constraint

Bio-Activity Profile

Function

Anticancer Antitumor

TargetA549

Activity11.71 μM

MethodIC50