Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length496 amino acids

Chemical FormulaC2408H3867N625O706S15

DescriptionStandard

        KQTRSVKMFLCCWLALGALIPLTLATDPGVKVKLTAKGLEYGRQLGMAAIQKKLKTIRVPDISGKASVSPIGTVQYSLTNLQIVDVGLPTSTVALVPGTGVRLSISKAFIRLDGNWRVKYLRIIKDSGSFDLNVSDLTVGASIAIKSDETGRPTVNSVGCEATVGSASIHFHGGASWLYNLFKDFIDKAIRDALQNQICPLVTDAVSDLNPQLKTLNVLAKVDQYAEIEYSMVSSPAVTTSSIELGLKGEFYNIGKRQEPPFSAAAFDLPPQTDNMLYVGLSAFTANSAAFVYSTAGALSLYVTDDMVPRASPIRLNTRTFGAFIPQIAERFPGLMVKLLVKTSETPVVTFEPNNTTVQATGTVTAYAIQPNATLSPLFVLNLESSASARLFVNVMRVAGNVTLNKMDLTLGTSYVGEFKVTALNSVFQMVLKSVVVPQLNVQLAKGYPLPTIGKMTLVNTKLQVLKGYMLIGTDVQFNSTHGASQDSFLPWGTTL
    

Molecular Weight53350.20 Da

Isoelectric Point (pI)9.26

Net Charge (pH 7.0)10.00

Net Charge (pH 7.4) 9.49

Charge Density (pH 7.0) 0.0202

GRAVY Index0.20

Hydrophobic Moment 0.79

Boman Index0.16

Instability Index27.33

Aliphatic Index 101.59

Aromaticity 0.0786

Extinction Coeff. Reduced 42860.00

Extinction Coeff. Oxidized 43110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0209155 VERIFIED: NO

Provenance & Taxonomy

OrganismGasterosteus aculeatus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence