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MYP_067031
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Basic Information
T20v1(T20 [H6R; S7E; L8,26I; I9L; E10V; Q13,21R; N14I; L24R; E25D])
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
36 amino acids
C207H319N57O60
Standard
Sequence
YTSLIREILVESRIQQEKNERELRDIDKWASLWNWF
Physicochemical Analysis
4566.09 Da
5.15
-1.23
-1.44
-0.0341
-0.82
0.80
-0.20
45.41
97.50
0.1389
17990.00
17990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1963.44
-14.00
70.0
59.0
155.0
324.0
8.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004381 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 92BR020 | U87 cells
0.17 μg/mL
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperOptimization of peptidic HIV-1 fusion inhibitor T20 by phage display. | Chen G, Cook JD, Ye W, Lee JE, Sidhu SS. | Protein Sci. 2019 Aug;28(8):1501-1512. | DOI:10.1002/pro.3669 | PMID:31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
RECORD: Rec_0010203 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 N43 | U87 cells
0.06 μg/mL
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperOptimization of peptidic HIV-1 fusion inhibitor T20 by phage display. | Chen G, Cook JD, Ye W, Lee JE, Sidhu SS. | Protein Sci. 2019 Aug;28(8):1501-1512. | DOI:10.1002/pro.3669 | PMID:31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
RECORD: Rec_0054014 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 N43:inhibition of virus infection in U87 cells
0.06 μg/mL
IC50
PaperPubMed PMID: 31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
RECORD: Rec_0059285 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 94UG103:inhibition of pseudovirus infection in U87 cells
0.06 μg/mL
IC50
PaperPubMed PMID: 31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
RECORD: Rec_0130974 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 92BR020:inhibition of pseudovirus infection in U87 cells
0.17 μg/mL
IC50
PaperPubMed PMID: 31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
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