Peptide Database

Peptide NameSC18EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC111H166N24O35

DescriptionStandard

        WEEWDKKIEEYTKKIEEL
    

Molecular Weight2396.65 Da

Isoelectric Point (pI)4.55

Net Charge (pH 7.0)-3.23

Net Charge (pH 7.4) -3.45

Charge Density (pH 7.0) -0.1793

GRAVY Index-1.73

Hydrophobic Moment 0.64

Boman Index-0.32

Instability Index85.38

Aliphatic Index 65.00

Aromaticity 0.1667

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 995.24

LogP -3.27

H-bond Donors 34.0

H-bond Acceptors 32.0

Rotatable Bonds 84.0

Heavy Atoms 170.0

Ring Count 5.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0205580 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 HXB2 | TZM-bl cells

Activity2 μM

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. | Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y. | Viruses. 2019 Jul 3;11(7):609. | DOI:10.3390/v11070609 | PMID:31277353 PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0281703 VERIFIED: YES